Selected Publications - Exercise Immunology

Baker FL, Smith KA, Mylabathula PL, Zúñiga TM, Diak DM, Batatinha H, Niemiro GM, Seckeler MD, Pedlar CR, O'Connor DP, Colombo J, Katsanis E, Simpson RJ. Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition. Cancer Res Commun. 2024 May 13;4(5):1253-1267. doi: 10.1158/2767-9764.CRC-23-0570. PMID: 38592213; PMCID: PMC11090081.
Fiuza-Luces C, Valenzuela P, Galvez B, Rameriz M, Lopez-Soto A, Simpson RJ, Lucia A. The effect of physical exercise on anticancer immunity. Nature reviews. Immunology, 10.1038/s41577-023-00943-0. Advance online publication. doi.org/10.1038/s41577-023-00943-0
Smith KA, Zúñiga TM, Baker FL, Batatinha H, Pedlar CR, Burgess SC, Gustafson MP, Katsanis E, Simpson RJ. COVID-19 vaccination produces exercise-responsive SARS-CoV-2-specific T-cells regardless of infection history. J Sport Health Sci. 2023 Jul 1:S2095-2546(23)00061-3. doi: 10.1016/j.jshs.2023.06.006. Online ahead of print. PMID: 37399887
Crane JC, Gordon MJ, Basen-Engquist K, Ferrajoli A, Markofski MM, Lee CY, Fares S, Simpson RJ, LaVoy EC. Relationships between T-lymphocytes and physical function in adults with chronic lymphocytic leukemia: Results from the HEALTH4CLL pilot study. Eur J Haematol. 2023 Mar 22. doi: 10.1111/ejh.13958. Online ahead of print. PMID: 36946440
Batatinha H, Diak DM, Niemiro GM, Baker FL, Smith KA, Zúñiga TM, Mylabathula PL, Seckeler MD, Lau B, LaVoy EC, Gustafson MP, Katsanis E, Simpson RJ. Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice. Front Immunol. 2023 Apr 3;14:1067369. doi: 10.3389/fimmu.2023.1067369. eCollection 2023. PMID: 37077913 Free PMC article.
Baker FL, Zúñiga TM, Smith KA, Batatinha H, Kulangara TS, Seckeler MD, Burgess SC, Katsanis E, Simpson RJ. Exercise mobilizes diverse antigen specific T-cells and elevates neutralizing antibodies in humans with natural immunity to SARS CoV-2. Brain Behav Immun Health. 2023 Jan 31:100600. doi: 10.1016/j.bbih.2023.100600. Online ahead of print. PMID: 36743994
Zúñiga TM, Baker FL, Smith KA, Batatinha H, Lau B, Burgess SC, Gustafson MP, Katsanis E, Simpson RJ. Clonal Kinetics and Single-Cell Transcriptional Profiles of T Cells Mobilized to Blood by Acute Exercise. Med Sci Sports Exerc. 2023 Jan 26. doi: 10.1249/MSS.0000000000003130. Online ahead of print. PMID: 36719647
Zúñiga TM, Baker FL, Smith KA, Batatinha H, Lau B, Gustafson MP, Katsanis E, Simpson RJ. Acute exercise mobilizes NKT-like cells with a cytotoxic transcriptomic profile but does not augment the potency of cytokine-induced killer (CIK) cells. 2022 Sep 14;13:938106. doi:10.3389/fimmu.2022.938106. eCollection 2022. PMID: 36189306
Rosa-Neto JC, Lira FS, Little JP, Landells G, Islam H, Chazaud B, Pyne DB, Teixeira AM, Batatinha H, Moura Antunes B, Guerra Minuzzi L, Palmowski J, Simpson RJ, Krüger K. Immunometabolism-fit: How exercise and training can modify T cell and macrophage metabolism in health and disease. Exerc Immunol Rev. 2022;28:29-46. PMID: 35452394.
Niemiro GM, Coletta AM, Agha NH, Mylabathula PL, Baker FL, Brewster AM, Bevers TB, Fuentes-Mattei E, Basen-Engquist K, Katsanis E, Gilchrist SC, Simpson RJ. Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial. Immun Ageing. 2022 Mar 23;19(1):17. doi: 10.1186/s12979-022-00266-z. PMID: 35321743.
Valenzuela PL, Saco-Ledo G, Santos-Lozano A, Morales JS, Castillo-García A, Simpson RJ, Lucia A, Fiuza-Luces C. Exercise Training and Natural Killer Cells in Cancer Survivors: Current Evidence and Research Gaps Based on a Systematic Review and Meta-analysis. Sports Med Open.2022 Mar 4;8(1):36. doi:10.1186/s40798-022-00419-w. PMID: 35244811.
Batatinha H, Baker FL, Smith KA, Zúñiga TM, Pedlar CR, Burgess SC, Katsanis E, Simpson RJ. Recent COVID-19 vaccination has minimal effects on the physiological responses to graded exercise in physically active healthy people. J Appl Physiol (1985). 2022 Feb 1;132(2):275-282. doi: 10.1152/japplphysiol.00629.2021. Epub 2021 Dec 9. PubMed PMID: 34882029; PubMed Central PMCID: PMC8799387.
Baker FL, Smith KA, Zúñiga TM, Batatinha H, Niemiro GM, Pedlar CR, Burgess SC, Katsanis E, Simpson RJ. Acute exercise increases immune responses to SARS CoV-2 in a previously infected man. Brain Behav Immun Health. 2021 Dec;18:100343. doi: 10.1016/j.bbih.2021.100343. Epub 2021 Sep 8. PubMed PMID: 34514439; PubMed Central PMCID: PMC8423674.
Simpson RJ, Boßlau TK, Weyh C, Niemiro GM, Batatinha H, Smith KA, Krüger K. Exercise and adrenergic regulation of immunity. Brain Behav Immun. 2021 Oct;97:303-318. doi: 10.1016/j.bbi.2021.07.010. Epub 2021 Jul 21. Review. PubMed PMID: 34302965.
Gustafson MP, Wheatley-Guy CM, Rosenthal AC, Gastineau DA, Katsanis E, Johnson BD, Simpson RJ. Exercise and the immune system: taking steps to improve responses to cancer immunotherapy. J Immunother Cancer. 2021 Jul;9(7). doi: 10.1136/jitc-2020-001872. Review. PubMed PMID: 34215686; PubMed Central PMCID: PMC8256759.
Coletta AM, Agha NH, Baker FL, Niemiro GM, Mylabathula PL, Brewster AM, Bevers TB, Fuentes-Mattei E, Basen-Engquist K, Gilchrist SC, Simpson RJ. The impact of high-intensity interval exercise training on NK-cell function and circulating myokines for breast cancer prevention among women at high risk for breast cancer. Breast Cancer Res Treat. 2021 Jun;187(2):407-416. doi: 10.1007/s10549-021-06111-z. Epub 2021 Feb 8. PubMed PMID: 33555464; PubMed Central PMCID: PMC8189992.
Kunz HE, Agha NH, Hussain M, LaVoy EC, Smith KA, Mylabathula P, Diak D, Baker FL, O'Connor DP, Bond RA, Katsanis E, Bollard CM, Simpson RJ. The effects of β₁ and β₁₊₂ adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: implications for cellular therapy and the anti-viral immune effects of exercise. Cell Stress Chaperones. 2020 Nov;25(6):993-1012. doi: 10.1007/s12192-020-01136-7. Epub 2020 Aug 10. PubMed PMID: 32779001; PubMed Central PMCID: PMC7591642.
Simpson RJ, Katsanis E. The immunological case for staying active during the COVID-19 pandemic. Brain Behav Immun. 2020 Jul;87:6-7. doi: 10.1016/j.bbi.2020.04.041. Epub 2020 Apr 18. Review. PubMed PMID: 32311497; PubMed Central PMCID: PMC7165095.
Simpson RJ, Campbell JP, Gleeson M, Krüger K, Nieman DC, Pyne DB, Turner JE, Walsh NP. Can exercise affect immune function to increase susceptibility to infection?. Exerc Immunol Rev. 2020;26:8-22. Review. PubMed PMID: 32139352.
Simpson RJ. 'Working-out' the link between inflammation and brain health. Brain Behav Immun. 2019 Nov;82:6-7. doi: 10.1016/j.bbi.2019.08.199. Epub 2019 Sep 3. PubMed PMID: 31491489.
Duggal NA, Niemiro G, Harridge SDR, Simpson RJ, Lord JM. Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?. Nat Rev Immunol. 2019 Sep;19(9):563-572. doi: 10.1038/s41577-019-0177-9. Review. PubMed PMID: 31175337.
Graff RM, Kunz HE, Agha NH, Baker FL, Laughlin M, Bigley AB, Markofski MM, LaVoy EC, Katsanis E, Bond RA, Bollard CM, Simpson RJ. β₂-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans. Brain Behav Immun. 2018 Nov;74:143-153. doi: 10.1016/j.bbi.2018.08.017. Epub 2018 Aug 30. PubMed PMID: 30172948; NIHMSID:NIHMS1020687.
Kunz HE, Spielmann G, Agha NH, O'Connor DP, Bollard CM, Simpson RJ. A single exercise bout augments adenovirus-specific T-cell mobilization and function. Physiol Behav. 2018 Oct 1;194:56-65. doi: 10.1016/j.physbeh.2018.04.035. Epub 2018 Apr 30. PubMed PMID: 29723594.
Rooney BV, Bigley AB, LaVoy EC, Laughlin M, Pedlar C, Simpson RJ. Lymphocytes and monocytes egress peripheral blood within minutes after cessation of steady state exercise: A detailed temporal analysis of leukocyte extravasation. Physiol Behav. 2018 Oct 1;194:260-267. doi: 10.1016/j.physbeh.2018.06.008. Epub 2018 Jun 7. PubMed PMID: 29885920.
Agha NH, Baker FL, Kunz HE, Graff R, Azadan R, Dolan C, Laughlin MS, Hosing C, Markofski MM, Bond RA, Bollard CM, Simpson RJ. Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β₂-adrenergic receptor. Brain Behav Immun. 2018 Feb;68:66-75. doi: 10.1016/j.bbi.2017.10.001. Epub 2017 Oct 7. PubMed PMID: 29017969; PubMed Central PMCID: PMC6980177.
Simpson RJ, Bigley AB, Agha N, Hanley PJ, Bollard CM. Mobilizing Immune Cells With Exercise for Cancer Immunotherapy. Exerc Sport Sci Rev. 2017 Jul;45(3):163-172. doi: 10.1249/JES.0000000000000114. Review. PubMed PMID: 28418996; PubMed Central PMCID: PMC6814300.
Peake JM, Neubauer O, Walsh NP, Simpson RJ. Recovery of the immune system after exercise. J Appl Physiol (1985). 2017 May 1;122(5):1077-1087. doi: 10.1152/japplphysiol.00622.2016. Epub 2016 Dec 1. Review. PubMed PMID: 27909225.
Simpson RJ. Aging and inflammation: Directing traffic through physical activity. Brain Behav Immun. 2016 Aug;56:10-1. doi: 10.1016/j.bbi.2016.05.015. Epub 2016 May 17. PubMed PMID: 27223097.
Spielmann G, Bollard CM, Kunz H, Hanley PJ, Simpson RJ. A single exercise bout enhances the manufacture of viral-specific T-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy. Sci Rep. 2016 May 16;6:25852. doi: 10.1038/srep25852. PubMed PMID: 27181409; PubMed Central PMCID: PMC4867645.
Simpson RJ, Bigley AB, Spielmann G, LaVoy EC, Kunz H, Bollard CM. Human cytomegalovirus infection and the immune response to exercise. Exerc Immunol Rev. 2016;22:8-27. Review. PubMed PMID: 26853134.
Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the Regulation of Immune Functions. Prog Mol Biol Transl Sci. 2015;135:355-80. doi: 10.1016/bs.pmbts.2015.08.001. Epub 2015 Sep 5. Review. PubMed PMID: 26477922.
Simpson RJ. Fitness deficits in long-term ALL survivors. Blood. 2015 May 28;125(22):3366-8. doi: 10.1182/blood-2015-04-638221. PubMed PMID: 26022049.
LaVoy EC, Bollard CM, Hanley PJ, Blaney JW, O'Connor DP, Bosch JA, Simpson RJ. A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults. Exerc Immunol Rev. 2015;21:144-53. PubMed PMID: 25826370.
Spielmann G, Bollard CM, Bigley AB, Hanley PJ, Blaney JW, LaVoy EC, Pircher H, Simpson RJ. The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans. Brain Behav Immun. 2014 Jul;39:142-51. doi: 10.1016/j.bbi.2013.05.003. Epub 2013 May 15. PubMed PMID: 23684819.
Bigley AB, Rezvani K, Chew C, Sekine T, Pistillo M, Crucian B, Bollard CM, Simpson RJ. Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Brain Behav Immun. 2014 Jul;39:160-71. doi: 10.1016/j.bbi.2013.10.030. Epub 2013 Nov 5. PubMed PMID: 24200514.
Simpson RJ, Lowder TW, Spielmann G, Bigley AB, LaVoy EC, Kunz H. Exercise and the aging immune system. Ageing Res Rev. 2012 Jul;11(3):404-20. doi: 10.1016/j.arr.2012.03.003. Epub 2012 Mar 21. Review. PubMed PMID: 22465452.
Simpson RJ. Aging, persistent viral infections, and immunosenescence: can exercise "make space"?. Exerc Sport Sci Rev. 2011 Jan;39(1):23-33. doi: 10.1097/JES.0b013e318201f39d. Review. PubMed PMID: 21088603.
Simpson RJ, Florida-James GD, Cosgrove C, Whyte GP, Macrae S, Pircher H, Guy K. High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. J Appl Physiol (1985). 2007 Jul;103(1):396-401. doi: 10.1152/japplphysiol.00007.2007. Epub 2007 Mar 22. PubMed PMID: 17379755.

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Selected Publications - Exercise Immunology