Selected Publications - Human Space Exploration

Krieger SS, Zwart SR, Mehta S, Wu H, Simpson RJ, Smith SM, Crucian B. Alterations in Saliva and Plasma Cytokine Concentrations During Long-Duration Spaceflight. Front Immunol. 2021 Aug 24;12:725748. doi: 10.3389/fimmu.2021.725748. eCollection 2021. PMID: 34504500
Mylabathula PL, Diak DM, Baker FL, Niemiro GM, Markofski MM, Crucian BE, Katsanis E, Simpson RJ. IL-2 and Zoledronic Acid Therapy Restores the In Vivo Anti-Leukemic Activity of Human Lymphocytes Pre-Exposed to Simulated Microgravity. Front Biosci (Landmark Ed). 2022 Jul 8;27(7):215. doi: 10.31083/j.fbl2707215. PMID: 35866402
Crucian BE, Makedonas G, Sams CF, Pierson DL, Simpson R, Stowe RP, Smith SM, Zwart SR, Krieger SS, Rooney B, Douglas G, Downs M, Nelman-Gonzalez M, Williams TJ, Mehta S. Countermeasures-based Improvements in Stress, Immune System Dysregulation and Latent Herpesvirus Reactivation onboard the International Space Station - Relevance for Deep Space Missions and Terrestrial Medicine. Neurosci Biobehav Rev. 2020 Aug;115:68-76. doi: 10.1016/j.neubiorev.2020.05.007. Epub 2020 May 25. Review. PubMed PMID: 32464118.
Mylabathula P, Li L, Bigley A, Markofski M, Crucian B, Mehta S, Pierson D, Laughlin M, Rezvani K, Simpson R. Simulated microgravity disarms human NK-cells and inhibits anti-tumor cytotoxicity in vitro. Acta Astronautica. 2020/03.
Agha NH, Baker FL, Kunz HE, Spielmann G, Mylabathula PL, Rooney BV, Mehta SK, Pierson DL, Laughlin MS, Markofski MM, Crucian BE, Simpson RJ. Salivary antimicrobial proteins and stress biomarkers are elevated during a 6-month mission to the International Space Station. J Appl Physiol (1985). 2020 Feb 1;128(2):264-275. doi: 10.1152/japplphysiol.00560.2019. Epub 2019 Nov 21. PubMed PMID: 31751178; PubMed Central PMCID: PMC7864226
Agha NH, Mehta SK, Rooney BV, Laughlin MS, Markofski MM, Pierson DL, Katsanis E, Crucian BE, Simpson RJ. Exercise as a countermeasure for latent viral reactivation during long duration space flight. FASEB J. 2020 Feb;34(2):2869-2881. doi: 10.1096/fj.201902327R. Epub 2020 Jan 3. PubMed PMID: 31908052.
Makedonas G, Mehta S, Choukèr A, Simpson RJ, Marshall G, Orange JS, Aunon-Chancellor S, Smith SM, Zwart SR, Stowe RP, Heer M, Ponomarev S, Whitmire A, Frippiat JP, Douglas GL, Krieger SS, Lorenzi H, Buchheim JI, Ginsburg GS, Ott CM, Downs M, Pierson D, Baecker N, Sams C, Crucian B. Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions. Front Immunol. 2019;10:2407. doi: 10.3389/fimmu.2019.02407. eCollection 2019. PubMed PMID: 31681296; PubMed Central PMCID: PMC6797618.
Bigley AB, Agha NH, Baker FL, Spielmann G, Kunz HE, Mylabathula PL, Rooney BV, Laughlin MS, Mehta SK, Pierson DL, Crucian BE, Simpson RJ. NK cell function is impaired during long-duration spaceflight. J Appl Physiol (1985). 2019 Apr 1;126(4):842-853. doi: 10.1152/japplphysiol.00761.2018. Epub 2018 Nov 1. PubMed PMID: 30382809.
Spielmann G, Agha N, Kunz H, Simpson RJ, Crucian B, Mehta S, Laughlin M, Campbell J. B cell homeostasis is maintained during long-duration spaceflight. J Appl Physiol (1985). 2019 Feb 1;126(2):469-476. doi: 10.1152/japplphysiol.00789.2018. Epub 2018 Nov 29. PubMed PMID: 30496712; PubMed Central PMCID: PMC6397409.
Crucian BE, Choukèr A, Simpson RJ, Mehta S, Marshall G, Smith SM, Zwart SR, Heer M, Ponomarev S, Whitmire A, Frippiat JP, Douglas GL, Lorenzi H, Buchheim JI, Makedonas G, Ginsburg GS, Ott CM, Pierson DL, Krieger SS, Baecker N, Sams C. Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions. Front Immunol. 2018;9:1437. doi: 10.3389/fimmu.2018.01437. eCollection 2018. Review. PubMed PMID: 30018614; PubMed Central PMCID: PMC6038331.
Spielmann G, Laughlin M, Kunz H, Crucian B, Quiriarte H, Mehta S, Pierson D, Simpson R. Latent viral reactivation is associated with changes in plasma antimicrobial protein concentrations during long-duration spaceflight. Acta Astronautica. 2018/05; 146:111-116.
Kunz H, Quiriarte H, Simpson RJ, Ploutz-Snyder R, McMonigal K, Sams C, Crucian B. Alterations in hematologic indices during long-duration spaceflight. BMC Hematol. 2017;17:12. doi: 10.1186/s12878-017-0083-y. eCollection 2017. PubMed PMID: 28904800; PubMed Central PMCID: PMC5590186.
Crucian B, Simpson RJ, Mehta S, Stowe R, Chouker A, Hwang SA, Actor JK, Salam AP, Pierson D, Sams C. Terrestrial stress analogs for spaceflight associated immune system dysregulation. Brain Behav Immun. 2014 Jul;39:23-32. doi: 10.1016/j.bbi.2014.01.011. Epub 2014 Jan 24. Review. PubMed PMID: 24462949.